Let $G$ be a graph with adjacency matrix $A(G)$, and let $D(G)$ be the diagonal matrix of the degrees of $G$. For any real $α\in[0,1]$, write $A_α(G)$ for the matrix $$A_α(G)=αD(G)+(1-α)A(G).$$ This paper presents some extremal results about the spectral radius $ρ(A_α(G))$ of $A_α(G)$ that generalize previous results about $ρ(A_0(G))$ and $ρ(A_{\frac{1}{2}}(G))$. In this paper, we give some results on graph perturbation for $A_α$-matrix with $α\in [0,1)$. As applications, we characterize all extremal trees with the maximum $A_α$-spectral radius in the set of all trees with prescribed degree sequence firstly. Furthermore, we characterize the unicyclic graphs that have the largest $A_α$-spectral radius for a given unicycilc degree sequence.