We propose the conjecture that the domination number $γ(G)$ of a $Δ$-regular graph $G$ with $Δ\geq 1$ is always at most its edge domination number $γ_e(G)$, which coincides with the domination number of its line graph. We prove that $γ(G)\leq \left(1+\frac{2(Δ-1)}{Δ2^Δ}\right)γ_e(G)$ for general $Δ\geq 1$, and $γ(G)\leq \left(\frac{7}{6}-\frac{1}{204}\right)γ_e(G)$ for $Δ=3$. Furthermore, we verify our conjecture for cubic claw-free graphs.