We show that for every fixed $\ell\in\mathbb{N}$, the set of $n$ with $n^\ell|\binom{2n}{n}$ has a positive asymptotic density $c_\ell$, and we give an asymptotic formula for $c_\ell$ as $\ell\to \infty$. We also show that $\# \{n\le x, (n,\binom{2n}{n})=1 \} \sim cx/\log x$ for some constant $c$. One novelty is a method to capture the effect of large prime factors of integers in general sequences.