Let $F$ be a $2$-regular graph of order $v$. The Oberwolfach problem, $OP(F)$, asks for a $2$-factorization of the complete graph on $v$ vertices in which each $2$-factor is isomorphic to $F$. In this paper, we give a complete solution to the Oberwolfach problem over infinite complete graphs, proving the existence of solutions that are regular under the action of a given involution free group $G$. We will also consider the same problem in the more general contest of graphs $F$ that are spanning subgraphs of an infinite complete graph $\mathbb{K}$ and we provide a solution when $F$ is locally finite. Moreover, we characterize the infinite subgraphs $L$ of $F$ such that there exists a solution to $OP(F)$ containing a solution to $OP(L)$.