Matrix mutation of skew-symmetrizable matrices is foundational in cluster algebra theory. Effective mutation invariants are essential for determining whether two matrices lie in the same mutation class. Casals~\cite{Casals} introduced a binary mutation invariant for skew-symmetric matrices. In this paper, we extend Casals' construction to the skew-symmetrizable setting. When the skew-symmetrizer $d_1,\dots, d_n$ is pairwise coprime, we obtain two distinct extensions of this invariant.