Let $G$ be a finite permutation group on $Ω$. An ordered sequence $(ω_1\ldots,ω_\ell)$ of elements of $Ω$ is an irredundant base for $G$ if the pointwise stabilizer is trivial and no point is fixed by the stabilizer of its predecessors. The minimal cardinality of a base is said to be the base size of $G$. If all irredundant bases of $G$ have the same cardinality, $G$ is said to be an IBIS group. In this paper, we classify the finite almost simple primitive IBIS groups whose base size is at least $6$.