A pair of graphs $(Γ,Σ)$ is said to be stable if the full automorphism group of $Γ\timesΣ$ is isomorphic to the product of the full automorphism groups of $Γ$ and $Σ$ and unstable otherwise, where $Γ\timesΣ$ is the direct product of $Γ$ and $Σ$. In this paper, we reduce the study of the stability of any pair of regular graphs $(Γ,Σ)$ with coprime valencies and vertex-transitive $Σ$ to that of $(Γ,K_2)$. Since the latter is well studied in the literature, this enables us to determine the stability of any pair of regular graphs $(Γ,Σ)$ with coprime valencies in the case when $Σ$ is vertex-transitve and the stability of $(Γ,K_2)$ is known.