A generic orthotope is an orthogonal polytope whose tangent cones are described by read-once Boolean functions. The purpose of this note is to develop a theory ofEhrhart polynomials for integral generic orthotopes. The most remarkable part of this theory is a relation between the number of lattice points in an integral generic orthotope $P$ and the number of unit cubes in $P$ of various floral types. This formula is facilitated through the introduction of a set of "local polynomials" defined for every read-once Boolean function.