We prove that there exists a constant $c_0$ such that for any $t \in \mathbb{N}$ and any $n\geq c_0 t$, if $A \subset S_n$ is a $t$-intersecting family of permutations then$|A|\leq (n-t)!$. Furthermore, if $|A|\ge 0.75(n-t)!$ then there exist $i_1,\ldots,i_t$ and $j_1,\ldots,j_t$ such that $σ(i_1)=j_1,\ldots,σ(i_t)=j_t$ holds for any $σ\in A$. This shows that the conjectures of Deza and Frankl (1977) and of Cameron (1988) on $t$-intersecting families of permutations hold for all $t \leq c_0 n$. Our proof method, based on hypercontractivity for global functions, does not use the specific structure of permutations, and applies in general to $t$-intersecting sub-families of `pseudorandom' families in $\{1,2,\ldots,n\}^n$, like $S_n$.