The sign coherence of $c$-vectors is one of the fundamental theorems of cluster algebras with principal coefficients. In 2019, Gekhtman and Nakanishi posed the asymptotic sign coherence conjecture for arbitrary cluster algebras of geometric type, which says sign coherence should eventually hold in any sufficiently generic infinite mutation sequence. We prove that their conjecture holds almost always for skew-symmetric cluster algebras of arbitrary rank. That is, we prove that with probability $1$, the sequence of $c$-vectors obtained by random mutation of an arbitrary quiver eventually becomes sign-coherent. Our results also establish the conjecture in full generality for many families of quivers by studying a new class of brog quivers.