The aim of this work is to compare symbolic and ordinary powers of monomial ideals using commutative algebra and combinatorics. Monomial ideals whose symbolic and ordinary powers coincide are called Simis ideals. Weighted monomial ideals are defined by assigning linear weights to monomials. We examine Simis and normally torsion-free ideals, relate some of the properties of monomial ideals and weighted monomial ideals, and present a structure theorem for edge ideals of $d$-uniform clutters whose ideal of covers is Simis in degree $d$. One of our main results is a combinatorial classification of when the dual of the edge ideal of a weighted oriented graph is Simis in degree $2$.