We show coordinate rings of open Richardson varieties are upper cluster algebras for any symmetrizable Kac--Moody type. We further show the coordinate rings of (generalized) open Richardson varieties on the twisted product of flag varieties are upper cluster algebras for any symmetrizable Kac--Moody type. This includes, as special cases, reduced double Bruhat cells, Bott-Samelson varieties, braid varieties. Our results generalize various results by Casals--Gorsky--Gorsky--Le--Shen--Simental and Galashin--Lam--Sherman-Bennett--Speyer in finite types.