In this paper, we prove that for any $k\ge 3$, there exist infinitely many minimal asymmetric $k$-uniform hypergraphs. This is in a striking contrast to $k=2$, where it has been proved recently that there are exactly $18$ minimal asymmetric graphs. We also determine, for every $k\ge 1$, the minimum size of an asymmetric $k$-uniform hypergraph.