Recently, Earl, Vander Meulen, and Van Tuyl characterized some families of Cohen-Macaulay or Buchsbaum circulant graphs discovered by Boros-Gurvich-Milani$\check{\text{c}}$, Brown-Hoshino, and Moussi. In this paper, we will characterize those families of circulant graphs which satisfy Serre's condition $S_2$. More precisely, we show that for some families of circulant graphs, $S_2$ property is equivalent to well-coveredness or Buchsbaumness, and for some other families it is equivalent to Cohen-Macaulayness. We also give examples of infinite families of circulant graphs which are Buchsbaum but not $S_2$, and vice versa.