Haglund's conjecture states that $\dfrac{\langle J_λ(q,q^k),s_μ\rangle}{(1-q)^{|λ|}} \in \mathbb{Z}_{\geq 0}[q]$ for all partitions $λ,μ$ and all non-negative integers $k$, where $J_λ$ is the integral form Macdonald symmetric function and $s_μ$ is the Schur function. This paper proves Haglund's conjecture in the cases when the pair $(λ,μ)$ satisfies $K_{λ,μ}=1$ or $K_{μ',λ'}=1$ where $K$ denotes the Kostka number. We also obtain some general results about the transition matrix between Macdonald symmetric functions and Schur functions.