Let $G=(V,E)$ be a simple graph. The concept of Inverse symmetric division deg index $(ISDD)$ was introduced in the chemical graph theory very recently. In spite of this, a few papers have already appeared with this index in the literature. Ghorbani et al. proposed Inverse symmetric division deg index and is defined as $$ISDD(G)=\sum\limits_{v_iv_j\in E(G)}\,\displaystyle{\frac{d_id_j}{d^2_i+d^2_j}},$$ where $d_i$ is the degree of the vertex $v_i$ in $G$. In this paper, we obtain some lower and upper bounds on the inverse symmetric division deg index $(ISDD)$ of graphs in terms of various graph parameters, with identifying extremal graphs. Moreover, we present two relations between the Inverse symmetric division deg index and the various topological indices of graphs. Finally, we give concluding remarks with future work.