In the sufficiently sparse case, we find the probability that a uniformly random bipartite graph with given degree sequence contains no edge from a specified set of edges. This enables us to enumerate loop-free digraphs and oriented graphs with given in-degree and out-degree sequences, and obtain subgraph probabilities. Our theorems are not restricted to the near-regular case. As an application, we determine the expected permanent of sparse or very dense random matrices with given row and column sums; in the regular case, our formula holds over all densities. We also draw conclusions about the degrees of a random orientation of a random undirected graph with given degrees, including its number of Eulerian orientations.