We show that any connected Cayley graph $Γ$ on an Abelian group of order $2n$ and degree $\tildeΩ(\log n)$ has at most $2^{n+1}(1 + o(1))$ independent sets. This bound is tight up to to the $o(1)$ term when $Γ$ is bipartite. Our proof is based on Sapozhenko's graph container method and uses the Plünnecke-Rusza-Petridis inequality from additive combinatorics.