Grothendieck polynomials $\mathfrak{G}_w$ of permutations $w\in S_n$ were introduced by Lascoux and Schützenberger in 1982 as a set of distinguished representatives for the K-theoretic classes of Schubert cycles in the K-theory of the flag variety of $\mathbb{C}^n$. We conjecture that the exponents of nonzero terms of the Grothendieck polynomial $\mathfrak{G}_w$ form a poset under componentwise comparison that is isomorphic to an induced subposet of $\mathbb{Z}^n$. When $w\in S_n$ avoids a certain set of patterns, we conjecturally connect the coefficients of $\mathfrak{G}_w$ with the Möbius function values of the aforementioned poset with $\hat{0}$ appended. We prove special cases of our conjectures for Grassmannian and fireworks permutations.