In the paper we develop new methods for calculating the two well-known topological indices, the degree-distance and the Gutman index. Firstly, we prove that the Wiener index of a double vertex-weighted graph can be computed from the Wiener indices of weighted quotient graphs with respect to a partition of the edge set that is coarser than $Θ^*$-partition. This result immediately gives a method for computing the degree-distance of any graph. Next, we express the degree-distance and the Gutman index of an arbitrary phenylene by using its hexagonal squeeze and inner dual. In addition, it is shown how these two indices of a phenylene can be obtained from the four quotient trees. Furthermore, reduction theorems for the Wiener index of a double vertex-weighted graph are presented. Finally, a formula for computing the Gutman index of a partial Hamming graph is obtained.