In the Grassmannian $Gr_{\mathbb{C}}(k,n)$ we have positroid varieties $Π_f$, each indexed by a bounded affine permutation $f$ and containing torus-fixed points $λ\in Π_f$. In this paper we consider the partially ordered set consisting of quadruples $(k,n,Π_f,λ)$ (or \textit{(positroid) pairs} $(Π_f,λ)$ for short). The partial order is the ordering given by the covering relation $\lessdot$ where $(Π_f',λ') \lessdot (Π_f,λ)$ if $Π_f'$ is obtained by $Π_f$ by \textit{deletion} or \textit{contraction.} Using the results of Snider [2010], we know that positroid varieties can be studied in a neighborhood of each of these points by \textit{affine pipe dreams.} Our main theorem provides a quick test of when a positroid variety is smooth at one of these given points. It is sufficient to test smoothness of a positroid variety by using the main result to test smoothness at each of these points. These results can also be applied to the question of whether Schubert varieties in flag manifolds are smooth at points given by 321-avoiding permutations, as studied in Graham/Kreimer [2020]. We have a secondary result, which describes the minimal singular positroid pairs in our ordering - these are the positroid pairs where any deletion or contraction causes it to become smooth.