We say that a subgraph $F$ of a graph $G$ is singular if the degrees $d_G(v)$ are all equal or all distinct for the vertices $v\in V(F)$. The singular Ramsey number Rs$(F)$ is the smallest positive integer $n$ such that, for every $m\geq n$, in every edge 2-coloring of $K_m$, at least one of the color classes contains $F$ as a singular subgraph. In a similar flavor, the singular Turán number Ts$(n,F)$ is defined as the maximum number of edges in a graph of order $n$, which does not contain $F$ as a singular subgraph. In this paper we initiate the study of these extremal problems. We develop methods to estimate Rs$(F)$ and Ts$(n,F)$, present tight asymptotic bounds and exact results.