We prove a general Ramsey theorem for trees with a successor operation. This theorem is a common generalization of the Carlson-Simpson Theorem and the Milliken Tree Theorem for regularly branching trees. Our theorem has a number of applications both in finite and infinite combinatorics. For example, we give a short proof of the unrestricted Nešetřil-Rödl theorem, and we recover the Graham-Rothschild theorem. Our original motivation came from the study of big Ramsey degrees - various trees used in the study can be viewed as trees with a successor operation. To illustrate this, we give a non-forcing proof of a theorem of Zucker on big Ramsey degrees.