It is a widely open problem to determine which monomials in the n-variable polynomial ring $K[x_1,...,x_n]$ over a field $K$ have the Gotzmann property, i.e. induce a Borel-stable Gotzmann monomial ideal. Since 2007, only the case $n \le 3$ was known. Here we solve the problem for the case $n = 4$. The solution involves a surprisingly intricate characterization.