We study the asymptotic size of the Karp-Sipser core in the configuration model with arbitrary degree distributions. The Karp-Sipser core is the induced subgraph obtained by iteratively removing all leaves and their neighbors through the leaf-removal process, and finally discarding any isolated vertices \cite{BCC}. Our main result establishes the convergence of the Karp-Sipser core size to an explicit fixed-point equation under general degree assumptions.The approach is based on analyzing the corresponding local weak limit of the configuration model - a unimodular Galton-Watson tree and tracing the evolution process of all vertex states under leaf-removal dynamics by use of the working mechanism of an enhanced version of Warning Propagation along with Node Labeling Propagation.