Topological indices are molecular descriptors that describe the properties of chemical compounds. These topological indices correlate specific physico-chemical properties like boiling point, enthalpy of vaporization, strain energy, and stability of chemical compounds. This article introduces a new graph operation based on central graph called central vertex-edge join and provides its results related to graph invariants like eccentric-connectivity index, connective eccentricity index, total-eccentricity index, average eccentricity index, Zagreb eccentricity indices, eccentric geometric-arithmetic index, eccentric atom-bond connectivity index, and Wiener index. Also, we discuss the distance spectrum of the central vertex-edge join of three regular graphs. Furthermore, we obtain new families of $D$-equienergetic graphs, which are non $D$-cospectral.