Let $G=(V,E)$ be a simple connected graph. A perfect matching (or Kekulé structure in chemical literature) of $G$ is a set of disjoint edges which covers all vertices of $G$. The anti-forcing number of $G$ is the smallest number of edges such that the remaining graph obtained by deleting these edges has a unique perfect matching and is denoted by $af(G)$. For every $m\in\mathbb{N}$, the $m$th power of $G$, denoted by $G^m$, is a graph with the same vertex set as $G$ such that two vertices are adjacent in $G^m$ if and only if their distance is at most $m$ in $G$. In this paper, we study the anti-forcing number of the powers of some graphs.