For a finite quiver $Q$, we study the reachability category $\mathbf{Reach}_Q$. We investigate the properties of $\mathbf{Reach}_Q$ from both a categorical and a topological viewpoint. In particular, we compare $\mathbf{Reach}_Q$ with $\mathbf{Path}_Q$, the category freely generated by $Q$. As a first application, we study the category algebra of $\mathbf{Reach}_Q$, which is isomorphic to the commuting algebra of $Q$. As a consequence, we recover, in a categorical framework, previous results obtained by Green and Schroll; we show that the commuting algebra of $Q$ is Morita equivalent to the incidence algebra of a poset, the reachability poset. We further show that commuting algebras are Morita equivalent if and only if the reachability posets are isomorphic. As a second application, we define persistent Hochschild homology of quivers via reachability categories.