In this paper, we present a classification of $2$-designs with $\gcd(r,λ)=1$ admitting flag-transitive automorphism groups. If $G$ is a flag-transitive automorphism group of a non-trivial $2$-design $\mathcal{D}$ with $\gcd(r,λ)=1$, then either $(\mathcal{D},G)$ is one of the known examples described in this paper, or $\mathcal{D}$ has $q = p^{d}$ points with $p$ prime and $G$ is a subgroup of $AΓL_{1}(q)$.