The plethysm product of Schur functions corresponds to composing polynomial representations of infinite general linear groups. Finding the plethysm coefficients $\langle s_ν\circ s_μ, s_λ\rangle$ that express an arbitrary plethysm $s_ν\circ s_μ$ as a sum $\sum_λ\langle s_ν\circ s_μ, s_λ\rangle s_λ$ of Schur functions is a fundamental open problem in algebraic combinatorics. We prove two stability theorems for plethysm coefficients under the operations of adding and/or joining an arbitrary partition to either $μ$ or $ν$. In both theorems $μ$ may be replaced with an arbitrary skew partition. As special cases we obtain all stability results on the plethysm product of two Schur functions in the literature to date. The proofs are entirely combinatorial using plethystic semistandard tableaux with positive and negative entries.