Let R(n,k) be the number of permutations of $\{1,2,\ldots,n\}$ with k alternating runs. In this paper, we establish the relationships between R(n,k) and the central factorial numbers of even indices as well as the number of signed permutations with a given number of alternating runs and the central factorial numbers of odd indices. The explicit formulas of the peak and left peak polynomials for permutations and the derivative polynomials of the tangent and secant functions are also established.