A signed dominating function of graph $Γ$ is a function $g :V(Γ) \longrightarrow \{-1,1\}$ such that $\sum_{u \in N[v]}g(u) >0$ for each $v \in V(Γ)$. The signed domination number $γ_{_S}(Γ)$ is the minimum weight of a signed dominating function on $Γ$. Let $G=\langle S \rangle$ be a finite group such that $e \not\in S=S^{-1}$. In this paper, we obtain the signed domination number of $Cay(S:G)$ based on cardinality of $S$. Also we determine the classification of group $G$ by $|S|$ and $γ_{_S}(Cay(S:G))$.