We relativise the Thomassen--Woess definition of accessibility in graphs, defining what it means for a graph to be accessible relative to a peripheral system. In the case of locally finite, quasi-transitive graphs, we characterise relative accessibility in terms of a certain subring of the Boolean ring of the graph, and apply this to show that our definition agrees with the usual algebraic notion of relative accessibility in finitely generated groups. This implies, in particular, that relative accessibility is a quasi-isometry invariant amongst finitely generated groups, when the quasi-isometry coarsely preserves the left cosets of the peripheral subgroups. We also deduce a relative variant of Hamann's accessibility theorem on graphs with finitely generated cycle spaces.