In this paper, we find a strong new restriction on the structure of CI-groups. We show that, if $R$ is a generalised dihedral group and if $R$ is a CI-group, then for every odd prime $p$ the Sylow $p$-subgroup of $R$ has order $p$, or $9$. Consequently, any CI-group with quotient a generalised dihedral group has the same restriction, that for every odd prime $p$ the Sylow $p$-subgroup of the group has order $p$, or $9$. We also give a counter example to the conjecture that every BCI-group is a CI-group.