A key functionality of emerging connected autonomous systems such as smart cities, smart transportation systems, and the industrial Internet-of-Things, is the ability to process and learn from data collected at different physical locations. This is increasingly attracting attention under the terms of distributed learning and federated learning. However, in connected autonomous systems, data transfer takes place over communication networks with often limited resources. This paper examines algorithms for communication-efficient learning for linear regression tasks by exploiting the informativeness of the data. The developed algorithms enable a tradeoff between communication and learning with theoretical performance guarantees and efficient practical implementations.