This paper studies the minimum mean squared error (MMSE) of estimating $\mathbf{X} \in \mathbb{R}^d$ from the noisy observation $\mathbf{Y} \in \mathbb{R}^k$, under the assumption that the noise (i.e., $\mathbf{Y}|\mathbf{X}$) is a member of the exponential family. The paper provides a new lower bound on the MMSE. Towards this end, an alternative representation of the MMSE is first presented, which is argued to be useful in deriving closed-form expressions for the MMSE. This new representation is then used together with the Poincaré inequality to provide a new lower bound on the MMSE. Unlike, for example, the Cramér-Rao bound, the new bound holds for all possible distributions on the input $\mathbf{X}$. Moreover, the lower bound is shown to be tight in the high-noise regime for the Gaussian noise setting under the assumption that $\mathbf{X}$ is sub-Gaussian. Finally, several numerical examples are shown which demonstrate that the bound performs well in all noise regimes.