Testing the equality of two conditional distributions is crucial in various modern applications, including transfer learning and causal inference. Despite its importance, this fundamental problem has received surprisingly little attention in the literature, with existing works focusing exclusively on global two-sample conditional distribution testing. Based on distance and kernel methods, this paper presents the first unified framework for both global and local two-sample conditional distribution testing. To this end, we introduce distance and kernel-based measures that characterize the homogeneity of two conditional distributions. Drawing from the concept of conditional U-statistics, we propose consistent estimators for these measures. Theoretically, we derive the convergence rates and the asymptotic distributions of the estimators under both the null and alternative hypotheses. Utilizing these measures, along with a local bootstrap approach, we develop global and local tests that can detect discrepancies between two conditional distributions at global and local levels, respectively. Our tests demonstrate reliable performance through simulations and real data analysis.