The interpretability of generative models is considered a key factor in demonstrating their effectiveness and controllability. The generated data are believed to be determined by latent variables that are not directly observable. Therefore, disentangling, decoupling, decomposing, causal inference, or performing Independent Component Analysis (ICA) in the latent variable space helps uncover the independent factors that influence the attributes or features affecting the generated outputs, thereby enhancing the interpretability of generative models. As a generative model, Variational Autoencoders (VAEs) combine with variational Bayesian inference algorithms. Using VAEs, the inverse process of ICA can be equivalently framed as a variational inference process. In some studies, Gaussian processes (GPs) have been introduced as priors for each dimension of latent variables in VAEs, structuring and separating each dimension from temporal or spatial perspectives, and encouraging different dimensions to control various attributes of the generated data. However, GPs impose a significant computational burden, resulting in substantial resource consumption when handling large datasets. Essentially, GPs model different temporal or spatial structures through various kernel functions. Structuring the priors of latent variables via kernel functions-so that different kernel functions model the correlations among sequence points within different latent dimensions-is at the core of achieving disentanglement in VAEs. The proposed Structured Kernel Regression VAE (SKR-VAE) leverages this core idea in a more efficient way, avoiding the costly kernel matrix inversion required in GPs. This research demonstrates that, while maintaining ICA performance, SKR-VAE achieves greater computational efficiency and significantly reduced computational burden compared to GP-VAE.