We study the problem of network regression, where one is interested in how the topology of a network changes as a function of Euclidean covariates. We build upon recent developments in generalized regression models on metric spaces based on Fréchet means and propose a network regression method using the Wasserstein metric. We show that when representing graphs as multivariate Gaussian distributions, the network regression problem requires the computation of a Riemannian center of mass (i.e., Fréchet means). Fréchet means with non-negative weights translates into a barycenter problem and can be efficiently computed using fixed point iterations. Although the convergence guarantees of fixed-point iterations for the computation of Wasserstein affine averages remain an open problem, we provide evidence of convergence in a large number of synthetic and real-data scenarios. Extensive numerical results show that the proposed approach improves existing procedures by accurately accounting for graph size, topology, and sparsity in synthetic experiments. Additionally, real-world experiments using the proposed approach result in higher Coefficient of Determination ($R^{2}$) values and lower mean squared prediction error (MSPE), cementing improved prediction capabilities in practice.