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stat.ML updates on arXiv.org

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Lifting Biomolecular Data Acquisition
Eli N. Weinstein, Andrei Slabodkin, Mattia G. Gollub, Kerry Dobb · 2025-12-18 · via stat.ML updates on arXiv.org

One strategy to scale up ML-driven science is to increase wet lab experiments' information density. We present a method based on a neural extension of compressed sensing to function space. We measure the activity of multiple different molecules simultaneously, rather than individually. Then, we deconvolute the molecule-activity map during model training. Co-design of wet lab experiments and learning algorithms provably leads to orders-of-magnitude gains in information density. We demonstrate on antibodies and cell therapies.