In many real world applications, reinforcement learning agents have to optimize multiple objectives while following certain rules or satisfying a list of constraints. Classical methods based on reward shaping, i.e. a weighted combination of different objectives in the reward signal, or Lagrangian methods, including constraints in the loss function, have no guarantees that the agent satisfies the constraints at all points in time and can lead to undesired behavior. When a discrete policy is extracted from an action-value function, safe actions can be ensured by restricting the action space at maximization, but can lead to sub-optimal solutions among feasible alternatives. In this work, we propose Constrained Q-learning, a novel off-policy reinforcement learning framework restricting the action space directly in the Q-update to learn the optimal Q-function for the induced constrained MDP and the corresponding safe policy. In addition to single-step constraints referring only to the next action, we introduce a formulation for approximate multi-step constraints under the current target policy based on truncated value-functions. We analyze the advantages of Constrained Q-learning in the tabular case and compare Constrained DQN to reward shaping and Lagrangian methods in the application of high-level decision making in autonomous driving, considering constraints for safety, keeping right and comfort. We train our agent in the open-source simulator SUMO and on the real HighD data set.