We derive information-theoretic lower bounds on the Bayes risk and generalization error of realizable machine learning models. In particular, we employ an analysis in which the rate-distortion function of the model parameters bounds the required mutual information between the training samples and the model parameters in order to learn a model up to a Bayes risk constraint. For realizable models, we show that both the rate distortion function and mutual information admit expressions that are convenient for analysis. For models that are (roughly) lower Lipschitz in their parameters, we bound the rate distortion function from below, whereas for VC classes, the mutual information is bounded above by $d_\mathrm{vc}\log(n)$. When these conditions match, the Bayes risk with respect to the zero-one loss scales no faster than $Ω(d_\mathrm{vc}/n)$, which matches known outer bounds and minimax lower bounds up to logarithmic factors. We also consider the impact of label noise, providing lower bounds when training and/or test samples are corrupted.