Regularized linear regression is central to machine learning, yet its high-dimensional behavior with informative priors remains poorly understood. We provide the first exact asymptotic characterization of training and test risks for maximum a posteriori (MAP) regression with Gaussian priors centered at a domain-informed initialization. Our framework unifies ridge regression, least squares, and prior-informed estimators, and -- using random matrix theory -- yields closed-form risk formulas that expose the bias-variance-prior tradeoff, explain double descent, and quantify prior mismatch. We also identify a closed-form minimizer of test risk, enabling a simple estimator of the optimal regularization parameter. Simulations confirm the theory with high accuracy. By connecting Bayesian priors, classical regularization, and modern asymptotics, our results provide both conceptual clarity and practical guidance for learning with structured prior knowledge.