We present a novel spectral machine learning (SML) method in screening for pancreatic mass using CT imaging. Our algorithm is trained with approximately 30,000 images from 250 patients (50 patients with normal pancreas and 200 patients with abnormal pancreas findings) based on public data sources. A test accuracy of 94.6 percents was achieved in the out-of-sample diagnosis classification based on a total of approximately 15,000 images from 113 patients, whereby 26 out of 32 patients with normal pancreas and all 81 patients with abnormal pancreas findings were correctly diagnosed. SML is able to automatically choose fundamental images (on average 5 or 9 images for each patient) in the diagnosis classification and achieve the above mentioned accuracy. The computational time is 75 seconds for diagnosing 113 patients in a laptop with standard CPU running environment. Factors that influenced high performance of a well-designed integration of spectral learning and machine learning included: 1) use of eigenvectors corresponding to several of the largest eigenvalues of sample covariance matrix (spike eigenvectors) to choose input attributes in classification training, taking into account only the fundamental information of the raw images with less noise; 2) removal of irrelevant pixels based on mean-level spectral test to lower the challenges of memory capacity and enhance computational efficiency while maintaining superior classification accuracy; 3) adoption of state-of-the-art machine learning classification, gradient boosting and random forest. Our methodology showcases practical utility and improved accuracy of image diagnosis in pancreatic mass screening in the era of AI.