This paper introduces a novel framework for estimation theory by introducing a second-order diagnostic for estimator design. While classical analysis focuses on the bias-variance trade-off, we present a more foundational constraint. This result is model-agnostic, domain-agnostic, and is valid for both parametric and non-parametric problems, Bayesian and frequentist frameworks. We propose to classify the estimators into three primary power regimes. We theoretically establish that any estimator operating in the `power-dominant regime' incurs an unavoidable mean-squared error penalty, making it structurally prone to sub-optimal performance. We propose a `safe-zone law' and make this diagnostic intuitive through two safe-zone maps. One map is a geometric visualization analogous to a receiver operating characteristic curve for estimators, and the other map shows that the safe-zone corresponds to a bounded optimization problem, while the forbidden `power-dominant zone' represents an unbounded optimization landscape. This framework reframes estimator design as a path optimization problem, providing new theoretical underpinnings for regularization and inspiring novel design philosophies.