Whitening is a classical technique in unsupervised learning that can facilitate estimation tasks by standardizing data. An important application is the estimation of latent variable models via the decomposition of tensors built from high-order moments. In particular, whitening orthogonalizes the means of a spherical Gaussian mixture model (GMM), thereby making the corresponding moment tensor orthogonally decomposable, hence easier to decompose. However, in the large-dimensional regime (LDR) where data are high-dimensional and scarce, the standard whitening matrix built from the sample covariance becomes ineffective because the latter is spectrally distorted. Consequently, whitened means of a spherical GMM are no longer orthogonal. Using random matrix theory, we derive exact limits for their dot products, which are generally nonzero in the LDR. As our main contribution, we then construct a corrected whitening matrix that restores asymptotic orthogonality, allowing for performance gains in spherical GMM estimation.