Cloud networks are difficult to monitor because they grow rapidly and the budgets for monitoring them are limited. We propose a framework for estimating network metrics, such as latency and packet loss, with guarantees on estimation errors for a fixed monitoring budget. Our proposed algorithms produce a distribution of probes across network paths, which we then monitor; and are based on A- and E-optimal experimental designs in statistics. Unfortunately, these designs are too computationally costly to use at production scale. We propose their scalable and near-optimal approximations based on the Frank-Wolfe algorithm. We validate our approaches in simulation on real network topologies, and also using a production probing system in a real cloud network. We show major gains in reducing the probing budget compared to both production and academic baselines, while maintaining low estimation errors, even with very low probing budgets.