Online social networks (OSNs) are emerging as the most popular mainstream platform for content cascade diffusion. In order to provide satisfactory quality of experience (QoE) for users in OSNs, much research dedicates to proactive content placement by using the propagation pattern, user's personal profiles and social relationships in open social network scenarios (e.g., Twitter and Weibo). In this paper, we take a new direction of popularity-aware content placement in a closed social network (e.g., WeChat Moment) where user's privacy is highly enhanced. We propose a novel data-driven holistic deep learning framework, namely DeepCP, for joint diffusion-aware cascade prediction and autonomous content placement without utilizing users' personal and social information. We first devise a time-window LSTM model for content popularity prediction and cascade geo-distribution estimation. Accordingly, we further propose a novel autonomous content placement mechanism CP-GAN which adopts the generative adversarial network (GAN) for agile placement decision making to reduce the content access latency and enhance users' QoE. We conduct extensive experiments using cascade diffusion traces in WeChat Moment (WM). Evaluation results corroborate that the proposed DeepCP framework can predict the content popularity with a high accuracy, generate efficient placement decision in a real-time manner, and achieve significant content access latency reduction over existing schemes.