Telegram has become a major space for political discourse and alternative media. However, its lack of moderation allows misinformation, extremism, and toxicity to spread. While prior research focused on these particular phenomena or topics, these have mostly been examined separately, and a broader understanding of the Telegram ecosystem is still missing. In this work, we fill this gap by conducting a large-scale analysis of the Italian Telegram sphere, leveraging a dataset of 186 million messages from 13,151 chats collected in 2023. Using network analysis, Large Language Models, and toxicity detection tools, we examine how different thematic communities form, align ideologically, and engage in harmful discourse within the Italian cultural context. Results show strong thematic and ideological homophily. We also identify mixed ideological communities where far-left and far-right rhetoric coexist on particular geopolitical issues. Beyond political analysis, we find that toxicity, rather than being isolated in a few extreme chats, appears widely normalized within highly toxic communities. Moreover, we find that Italian discourse primarily targets Black people, Jews, and gay individuals independently of the topic. Finally, we uncover common trend of intra-national hostility, where Italians often attack other Italians, reflecting regional and intra-regional cultural conflicts that can be traced back to old historical divisions. This study provides the first large-scale mapping of the Italian Telegram ecosystem, offering insights into ideological interactions, toxicity, and identity-targets of hate and contributing to research on online toxicity across different cultural and linguistic contexts on Telegram.