This paper studies a general class of stochastic population processes in which agents interact with one another over a network. Agents update their behaviors in a random and decentralized manner according to a policy that depends only on the agent's current state and an estimate of the macroscopic population state, given by a weighted average of the neighboring states. When the number of agents is large and the network is a complete graph (has all-to-all information access), the macroscopic behavior of the population can be well-approximated by a set of deterministic differential equations called a {\it mean-field approximation}. For incomplete networks such characterizations remained previously unclear, i.e., in general whether a suitable mean-field approximation exists for the macroscopic behavior of the population. The paper addresses this gap by establishing a generic theory describing when various mean-field approximations are accurate for \emph{arbitrary} interaction structures. Our results are threefold. Letting $W$ be the matrix describing agent interactions, we first show that a simple mean-field approximation that incorrectly assumes a homogeneous interaction structure is accurate provided $W$ has a large spectral gap. Second, we show that a more complex mean-field approximation which takes into account agent interactions is accurate as long as the Frobenius norm of $W$ is small. Finally, we compare the predictions of the two mean-field approximations through simulations, highlighting cases where using mean-field approximations that assume a homogeneous interaction structure can lead to inaccurate qualitative and quantitative predictions.